Figure 1.

(a) The mean (± standard deviation) plasma concentration–time profile for midazolam in 10 healthy volunteers. Each volunteer received oral midazolam 2 mg with (filled circles) and without (open circles) clotrimazole 10 mg three times daily for 5 days before the single-dose administration of midazolam. (b) The mean (± standard deviation) plasma concentration–time profile for 1-hydroxymidazolam in 10 healthy volunteers. Each volunteer received oral midazolam 2 mg with (filled circles) and without (open circles) clotrimazole 10 mg three times daily for 5 days before the single-dose administration of midazolam. Clotrimazole (—•—); Control (—○—)