Table 2.
Genotype frequencies of angiotensin-converting enzyme (ACE) I/D, bradykinin B2 receptor exon 1 (2/3) and exon 2 (c.C181T) polymorphism in 65 patients with ACE inhibitor (i)-induced angio-oedema and 65 control subjects under ACEi treatment but without angio-oedema episodes (control I)
| ACEi angio-oedema cases | ACEi controls | |||
|---|---|---|---|---|
| Gene polymorphism | Allele frequency (%) | n | Allele frequency (%) | n |
| ACE | ||||
| I/I | 0.18 | 10 | 0.17 | 12 |
| I/D | 0.24 | 35 | 0.24 | 29 |
| D/D | 0.34 | 20 | 0.35 | 24 |
| B2 receptor exon 1 | ||||
| 2/2 | 0.23 | 16 | 0.18 | 11 |
| 2/3 | 0.25 | 30 | 0.24 | 32 |
| 3/3 | 0.27 | 19 | 0.34 | 22 |
| B2 receptor exon2 | ||||
| C/C | 0.85 | 55 | 0.83 | 54 |
| C/T | 0.07 | 10 | 0.08 | 10 |
| T/T | 0.006 | 0 | 0.008 | 1 |