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. 2009 Dec 22;5:334. doi: 10.1038/msb.2009.91

Figure 6.

Figure 6

Cellular proliferation is controlled and confined by the integrated response of ERK1 and ERK2. (A) Integrated responses of double-phosphorylated ERK1 and ERK2 calculated in Figure 5B are depicted with symbols for control cells and cells over-expressing ERK1 or ERK2. The values correspond to CFU-E cells stimulated with Epo concentrations ranging from 0.001 to 50 U/ml. Assumed constant proliferation for very high doses of Epo is depicted by grey circles. The data points corresponding to the Epo concentration that was used for model calibration are indicated by dashed squares. Predicted proliferation by a nonlinear regression model is shown by a blue to red colour map, based on the measured CFU-E proliferation for these Epo concentrations as shown in Figure 5C. (B) Positive and negative contribution to average proliferation of double-phosphorylated ERK1 and ERK2 is depicted by a black line. Dashed lines indicate confidence intervals.