Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Gliotoxin: A prooxidant peroxiredoxin mimetic and experimental redox chemotherapeutic. The disulfide-based mycotoxin gliotoxin (60) causes catalytic oxidation of thioredoxin [reaction cycle (1)] and glutathione depletion with ROS formation [redox cycle (2)]. In addition, gliotoxin inactivates target proteins by either covalent modification or free radical damage mediated by redox cycling.
