FIG. 6.

Schematic diagram depicting electron transport, the action of substrates and inhibitors, and proposed sites of ROS production, as detected with H₂O₂ fluorescence and EPR spectroscopy. Straight lines with arrows, Forward electron transport. Dashed lines, Reverse transport. Dashed-dotted lines, Diffusion of Q compounds in complex III or of H₂O₂ out from the matrix, as shown. Dotted boxes, Complexes I, II, and III. X, Sites of inhibition by rotenone (ROT), stigmatellin (STIG), or antimycin A (ANT A). Dark arrows, Direction of superoxide release or conversion to H₂O₂.