Table 1. Enrichment of optimal codons at structurally sensitive sites in E. coli varies by GroEL dependency.

Amino acids	Zhou et al (odds ratio)	P	Non-substrates (odds ratio)	P	Class-III (odds ratio)	P	Class-II (odds ratio)	P	Class-I (odds ratio)	P
All	1.06	<0.001	1.09	1.16E−05	1.02	0.83	1.24	0.001	1.25	0.002
L/N/Q/S/T	1.25	5.29E−32	1.29	8.72E−16	1.08	0.51	1.59	8.36E−05	1.79	5.31E−05