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. 2010 Jan 19;6:344. doi: 10.1038/msb.2009.100

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Copyright © 2010, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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Intracellular concentrations of glycolytic, TCA cycle, and pentose phosphate pathway metabolites after exposure of trehalose-grown wild-type cells to sudden increase of glucose concentration to 110 mmol/l. (A) ATP, ADP, and AMP; (B) GTP, GDP, and GMP; (C) sum of adenine and guanine nucleotides; (D) energy charge, inorganic phosphate (Pi); (E) glycerol-3-phosphate (G3P); trehalose-6-phosphate (T6P); (F) glucose-6-phosphate (G6P); glucose-1-phosphate (G1P); (G) malate; (H) ribose-5-phosphate (R5P); ribose-1-phosphate (R1P); (I) fructose-6-phosphate (F6P); fructose-1,6-bisphosphate (F1,6P); (J) 6-phosphogluconate (6PG); phosphoribosyl pyrophosphate (PRPP); (K) alpha-ketoglutarate (alphaKG); (L) phosphoenolpyruvate (PEP); pooled 2 and 3-phosphoglycerate (2/3PG); 1,3-phosphodiglycerate (1,3diPG). Data shown represent the average of at least two independent experiments. Metabolite concentrations are provided in tabular form in Supplementary information II.