Table 1.

α-conotoxin BuIA kinetic constants for block of α3β2 nAChRs

	kon	koff	ki	IC50
	min−1 M−1	min−1	M	M
α3β2	1.12 (0.19–2.05) × 108	0.656 (0.483–0.829)	5.85 × 10−9	a5.72 × 10−9
aα3β4	4.68 (3.06–6.30) × 107	0.0111	2.38 × 10−8	2.77 × 10−8
α3β2,V111I	5.21 (0–18.2) × 107	2.614 (1.58–3.64)	4.91 × 10−8	8.98 (7.6–10.6) × 10−9
α3β2,F119Q	1.05 (0.864–1.24) × 108	0.0936 (0.0813–0.106)	8.91 × 10−10	7.35 (5.92–9.13) × 10−10
α3β2,T59D	6.72 (2.19–11.3) × 107	0.0448 (0.0274–0.0622)	6.65 × 10−10	5.66 (5.00–6.40) × 10−10
α3β2,T59G	1.17 (0.26–2.08) × 108	0.0581 (0.0489–0.0660)	5.01 × 10−10	3.62 (2.15–6.08) × 10−10
α3β2,T59K	6.03 (5.34–6.72) × 107	0.0178 (0.0164–0.0192)	2.95 × 10−10	2.43 (1.86–3.19) × 10−10
α3β2,T59S	2.83 (1.71–3.94) × 107	0.0878 (0.0636–0.112)	3.11 × 10−10	4.93 (4.30–5.68) × 10−10
α3β2,T59V	1.61 (1.08–2.14) × 108	0.301 (0.259–0.343)	1.87 × 10−9	1.08 (0.993–1.18) × 10−9

Numbers in parentheses are 95% confidence intervals

^aValues from (18).