Fig. 1.
Palindrome-mediated translocation in humans. (a) Schematic representation of the t(11;22)(q23;q11). The PATRR11 and the PATRR22 are located at the breakpoints on 11q23 and 22q11, respectively. (b) Palindromic sequence possesses the potential for forming a cruciform configuration. Short palindromic sequences have the potential to form such double-stranded cruciform structures by intra-strand base pairing in the single-stranded DNA. DNA sequences indicated by blue arrows are the complement for those depicted by red arrows.