Figure 4.

Administration of chondroitinase into a chronic injury setting affects gait characteristics. The Tread Scan system was used to analyze different parameters during locomotion. No difference in stride length (a) or stride time (b) was determined at before and after PN grafting time points between animals with PNGs spanning a chronic C5 contusion site treated with GDNF–PBS (white bars; n = 10) or GDNF–ChABC (gray bars; n = 14). However, animals that received GDNF–ChABC treatment of a chronic contusion site and ChABC of a distal DQ injury site (n = 13) before PN bridging had significantly longer stride lengths (c) and stride times (d) than GDNF–PBS-treated ones (n = 11) by 7 weeks after graft apposition. *p < 0.05. Error bars represent SEM.