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. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681

Figure 3. Ex vivo and in silico results for eight different experimental conditions are compared.

Figure 3

Ex vivo conditions (from [13]): the flow chamber surface was coated with P-selectin and/or ICAM-1 with or without immobilized CXCL1 chemokine. Mice were either WT or PI3Kγ knockouts (KO). Leukocytes that rolled and adhered within each of five fields of view were recorded during a 60-second observation interval. White bars are ex vivo means ± 1 SE. The paired black bars are ISWBC2 means ± 1 SD (20 populations containing 30 leukocytes each) for the same condition using the parameter values in Tables 4 and 5. ISWBC2 experiments that map to WT mouse counterparts used LFA1Clustering = true. Simulations of KO mice used the parameter setting LFA1Clustering = false.