Skip to main content
. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681

Figure 5. Robustness of ISWBC2s to changes in the LFA1RemovalRate, Pon, and RearForce.

Figure 5

Separate sets of in silico experiments, using the leukocyte parameter values in Table 4 and environment parameter values in Table 5, were completed while varying either (A) RearForce, (B) LFA1RemovalRate, or (C) Pon(high affinity lfa1-icam1) as indicated. Bars heights are ratios of ISWBC2-to-wet-lab results of rolling and adhesion data for both WT and KO mice of the type used for the experiments in Figure 3. Comparable adjustments of other parameters caused similar gradual changes in leukocyte rolling and adhesion data. The listed parameter values for rolling under Knockout also apply to the similarly shaded bar for the other three conditions.