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. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681

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Tang, Hunt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The percentage of leukocytes that sustained adhesion (color scale at right) were calculated for varying LFA1GridDensity and ICAM1Density values using the different hypothesized icam1 configurations discussed in the text. Lfa1 clustering was either disabled (left: A, C, E) or enabled (right: B, D, F). Icam1 was (A, B) dimeric, (C, D) dimeric and allowed to form linear tetramers upon ligand-binding, or (E, F) was preformed into nanoclusters. No sustained adhesion occurred when icam1 was monomeric (not shown).