Table 1. Targetable phenotypic attributes of leukocytes in vitro/ex vivo/in vivo: an abridged list.
Phenotypic Attribute | Reference |
Set A: previously targeted attributes | |
Characteristic jerky stop and go movement during rolling | [12],[50] |
Highly fluctuating rolling velocities | [12],[51] |
Larger rolling velocities observed at higher shear rates | [12],[52] |
Smaller rolling velocities at higher ligand substrate densities | [12],[52] |
Rolling a velocities on pselectin a match reported values | [12],[52] |
Small number of bonds within the contact zone, e.g., within 2–20 | [12],[53] |
Distance-time and velocity-time data for rolling a on a pselectin/vcam1 are indistinguishable from reported data | [12],[50],[51] |
Chemokines induce adhesion within seconds | [12],[54] |
Set B: currently targeted attributes | |
LFA-1 and ICAM-1 lateral mobility and diffusion | [55] |
LFA-1 nanocluster formation upon binding multivalent ligand | [2] |
ICAM-1 spatial configurations in vivo | [33]–[37],[56] |
Effect of phosphoinositide 3-kinase inhibitors on adhesion ex vivo | [13] |
Effect of phosphoinositide 3-kinase inhibitors on adhesion in vivo | [13] |
Set C: future targetable attributes | |
Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin | [57] |
Synergistic effect observed during neutrophil rolling on P- and E-selectin | [58] |
Effect of knocking out VAV1/3 guanine nucleotide exchange factors on neutrophil rolling | [20] |
Effect of inhibitors to other signaling molecules on cell arrest (pertussis toxin (PTx)-sensitive G proteins, p38 mitogen-activated protein kinase) | [57] |
We find that this model accounts for the nonlinear influence of experimentally induced visual motion on human postural behavior both in our data and in previously published results.
We use small caps when referring to the in silico components, features, measurements, and events.