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. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681

Table 1. Targetable phenotypic attributes of leukocytes in vitro/ex vivo/in vivo: an abridged list.

Phenotypic Attribute Reference
Set A: previously targeted attributes
Characteristic jerky stop and go movement during rolling [12],[50]
Highly fluctuating rolling velocities [12],[51]
Larger rolling velocities observed at higher shear rates [12],[52]
Smaller rolling velocities at higher ligand substrate densities [12],[52]
Rolling a velocities on pselectin a match reported values [12],[52]
Small number of bonds within the contact zone, e.g., within 2–20 [12],[53]
Distance-time and velocity-time data for rolling a on a pselectin/vcam1 are indistinguishable from reported data [12],[50],[51]
Chemokines induce adhesion within seconds [12],[54]
Set B: currently targeted attributes
LFA-1 and ICAM-1 lateral mobility and diffusion [55]
LFA-1 nanocluster formation upon binding multivalent ligand [2]
ICAM-1 spatial configurations in vivo [33][37],[56]
Effect of phosphoinositide 3-kinase inhibitors on adhesion ex vivo [13]
Effect of phosphoinositide 3-kinase inhibitors on adhesion in vivo [13]
Set C: future targetable attributes
Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin [57]
Synergistic effect observed during neutrophil rolling on P- and E-selectin [58]
Effect of knocking out VAV1/3 guanine nucleotide exchange factors on neutrophil rolling [20]
Effect of inhibitors to other signaling molecules on cell arrest (pertussis toxin (PTx)-sensitive G proteins, p38 mitogen-activated protein kinase) [57]

We find that this model accounts for the nonlinear influence of experimentally induced visual motion on human postural behavior both in our data and in previously published results.

a

We use small caps when referring to the in silico components, features, measurements, and events.