Skip to main content
. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681

Table 5. Experimental values for the blood-perfused micro-flow chamber and the cremaster muscle venule experiments and the corresponding ISWBC2 parameter values used for the two simulated experimental conditions.

Experiment Experimental Parameter Experimental Value Ref ISWBC Parameter ISWBC Value
I. Ex Vivo Blood Perfused Micro-flow chamber
P-Selectin 18 µg/mL [13] pselectin 15±5
ICAM-1 15 µg/mL [13] icam1 25±5
CXCL1 15 µg/mL [13] cxcl1 1
Shear 2.5 dyn/cm2 [13] RearForce 0.6
II. In Vivo Cremaster Muscle Venule
P-Selectina 1.02×107 molecules/cm2 [66] pselectin 12±5
ICAM-1a 8.90×107 molecules/cm2 [66] icam1 6±3
CXCL1 5 µg/mL [13] cxcl1 1
Shear 1–4 dyn/cm2 [52] RearForce 0.6
a

Neutrophils were incubated with radiolabelled mAbs to P-Selectin or ICAM-1 and analyzed by laser confocal microscopy. The receptor number is determined by the binding ratio between the fluorescence and immunoglobulin [66].