Figure 2.

Linked region for HDL-C on chromosome 16q21-24. (a) The position of microsatellite markers with the interval distance (cM) between them is indicated and below the line are the actual physical locations (Mb). Red markers are genome-wide scan markers and the other markers are from subsequent fine mapping. Position of the LOD score peak is shown in the box. Family identification numbers are indicated on the left side and segregating haplotypes for each family are shown. The positions of CETP, LCAT and CHST6 are indicated by arrowheads. The distance between arrows A and B corresponds to the initially identified linked region, which was narrowed down to the region between A and C. (b) Other known genes in the region of CHST6 are shown. Inside the box is the five SNP haplotype that had an increased frequency. Families indicated in bold carry the R162G mutation in CHST6.