Figure 3. Estimating the proportion of CD62L^high cells that become CD62L^low on each division.

The rate of differentiation (c) from CD62L^high to CD62L^low per division was calculated with three methods. In the first, the relative extra number of divisions to reach the peak proportion of OT-1 cells calculated between mice taking into consideration the adoptive transfer amount (n = 15, median c value = 0.212 [indicated by horizontal bar]). The second method calculates the number of divisions from the first day of measurement to the peak of infection in individual mice (n = 12, median c value = 0.199). The third calculates the number of divisions cells undergo in the spleen (n = 2, mean c value = 0.218).