Figure 4. Kinetic analysis of BER using a uracil-containing oligonucleotide duplex DNA substrate.
(B and C) Incorporation of [α-32P]dCMP was measured as a function of incubation time using various DT40 cell extracts. (B) Sequence of a 35-bp oligonucleotide containing a uracil residue. (C) Photographs of PhosphorImager analysis illustrating uracil-DNA BER are shown. (D) The relative amount of ligated uracil-BER product is represented.