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. 2010 Feb 19;5(2):e9298. doi: 10.1371/journal.pone.0009298

Figure 2. Variable effects of Na+ channel blockade in Scn5a +/− mice and SCN5A-mutated patients.

Figure 2

Ajmaline-induced increase in QRS interval (Y-axes) in 10 week- and >53 week-old WT (n = 11 and n = 10; open bars), mildly (n = 10 and n = 10; grey bars) and severely (n = 11 and n = 10; black bars) affected Scn5a +/− mice (left panel), and in young (6–31 years; mean = 22 years) and older (41–61 years; mean = 50 years) non-mutated (n = 18 and n = 17, open bars) and SCN5A-mutated patients with either mild (n = 12 and n = 11; grey filled bars) or severe (n = 7 and n = 12; black filled bars) QRS interval prolongation (right panel). *, ***, p<0.05 and p<0.001 respectively versus WT mice or non-mutated patients. †, p<0.05 versus Scn5a +/− mice or SCN5A-mutated patients with a mild phenotype. The difference between old mildly affected mice and old WT mice did not reach significance (p = 0.07). Same comment for the older patients.