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. 2010 Feb 19;5(2):e9313. doi: 10.1371/journal.pone.0009313

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Crews et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative image from a non-demented control case showing normal neuronal lysosomes (arrow). (B–D) Abnormal autophagosomes and accumulation of electrodense deposits (arrows) in intraneuronal membrane-bound structures in the brains of patients with DLB. (E) Representative image from a non tg mouse brain showing normal neuronal lysosomes (arrow). (F–H) Abnormal autophagosome morphology and accumulation of electrodense deposits (arrows) in intraneuronal membrane-bound structures in the brains of α-syn tg mice. Scale bar in panel (C) represents 0.5µm in all panels.