Figure 5. A switch in the genomic imprinting of H19 and IGF2.

There are six sites in H19 (shaded orange) and one in IGF2 (shaded blue) on chromosome 11 that are apparently heterozygous in patient 8 (five were validated by as-qPCR). In normal tissue, most detectable expression of H19 is from one allele, as expected for this imprinted, maternally expressed gene. Unexpectedly, in the tumor, nearly all detected expression is from the other, presumably paternal, allele. Observed nucleotides are from dbSNP[35].