Table 1.
Median response in 21 cytokines and chemokines.
| Cytokine | Unvac median (pg/ml) | Vac median (pg/ml) | Median fold difference | P value | |
|---|---|---|---|---|---|
| Pro-inflammatory cytokine | IFNγ | 1.6 | 1705 | 1066 | P < 0.0001 |
| TNFα | 18 | 226 | 13 | P < 0.0001 | |
| IL-2 | 1.6 | 17 | 11 | P < 0.0001 | |
| IL-1α | 4 | 145 | 36 | P < 0.0001 | |
| IL-6 | 227 | 855 | 4 | P = 0.0003 | |
| TH17 cytokine | IL-17 | 1.6 | 17 | 11 | P < 0.0001 |
| TH2 cytokine | IL-4 | 1.6 | 10 | 6 | P = 0.013 |
| IL-5 | 1.6 | 7 | 4 | P = 0.0005 | |
| IL-13 | 1.6 | 104 | 65 | P < 0.0001 | |
| Regulatory cytokine | IL-10 | 8 | 96 | 12 | P < 0.0001 |
| Chemokine | IL-8 | 1621 | 20,562 | 13 | P = 0.0073 |
| IP-10 | 99 | 2122 | 21 | P < 0.0001 | |
| MIP-1α | 1.6 | 454 | 284 | P < 0.0001 | |
| Growth factor | GCS-F | 1.6 | 21 | 13 | P = 0.012 |
| GM-CSF | 14 | 420 | 30 | P < 0.0001 | |
| No evidence of a difference between vaccinated and unvaccinated infants | IL12p70 | 1.6 | 1.6 | 1 | P = 0.49 |
| IL-15 | 1.6 | 1.6 | 1 | na | |
| Eotaxin | 1.6 | 7 | 4 | P = 0.13 | |
| MCP-1 | 6932 | 1560 | 0 | P = 0.54 | |
| IL-1β | 1.6 | 1.6 | 1 | P = 0.08 | |
| IL-7 | 1.6 | 1.6 | 1 | P = 0.12 | |
Supernatants from diluted blood samples stimulated with M.tb PPD for 6 days were tested for 21 cytokines and chemokines from unvaccinated (Unvac) and vaccinated (Vac) infants 3 months post-BCG vaccination. Median fold differences and P values for significance testing by the Mann–Whitney test are also presented (na is not applicable).