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. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: Cell Host Microbe. 2009 May 8;5(5):487–497. doi: 10.1016/j.chom.2009.05.002

Figure 1. In vitro IL-1β responses to Candida albicans are morphological stage dependent and blocked by caspase-1 inhibitor.

Figure 1

(a) IL-1β responses of normal PBMC primed for 3 h with LPS then stimulated with fixed preparations of C. albicans of different morphological stages at ~ 106/ml; (b) Inhibition of IL-1β responses after the addition of caspase-1 specific inhibitor, Z-YVAD-FMK; (c) Western blot of supernatants from PBMC stimulation probed with anti-IL-1β antibody; (d) IL-1β responses of bone-marrow derived macrophages from wild-type mice primed for 3 h with LPS then stimulated with C. albicans at ~ 106/ml; (e) Western blot of supernatants from BMDM stimulation probed with anti-IL-1β antibody, (f) and anti-caspase-1 antibody. (*** P < 0.001; ** P < 0.01; * P < 0.05)

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