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. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: Cell Host Microbe. 2009 May 8;5(5):487–497. doi: 10.1016/j.chom.2009.05.002

Figure 2. IL-1β responses to Candida albicans are dependent on TLR2 and dectin-1.

Figure 2

(a) Up-regulation of IL-1β mRNA by qPCR of macrophages from Tlr2-/-, Dect1-/- and wild-type mice stimulated for 8 h with C. albicans of different morphological stages at ~ 106/ml; (b) IL-1β protein levels in supernatants of macrophages from Tlr2-/-, Dect1-/- and wild-type mice stimulated overnight with C. albicans of different morphological stages at ~ 106/ml; (c) IL-1β responses of wild-type macrophages stimulated O/N with LPS at 500 ng/ml, β-glucan at 10 μg/ml or zymosan at 1 μg/ml alone, or primed for 6 h then removed and stimulated for an additional 8 h by C. albicans at ~ 106/ml. (*** P < 0.001; ** P < 0.01; * P < 0.05)

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