Figure 6. Innate PRRs enhance survival after oral infection with Candida albicans.
(a) Quantitative fungal burden of tongues, and (b) kidneys of Dect1-/- and wild-type (WT) mice after oral infection with C. albicans; (c) Kaplan-Meier survival plots of WT and Dect1-/- mice after infection (P = 0.0009); (d) Mean clinical severity score of Dect1-/- and WT after 3 or 7d of infection; (e) Quantitative fungal burden of tongues and (f) kidneys of Tlr2-/- and wild-type (WT) mice after oral infection with C. albicans; (g) Kaplan-Meier survival plots of WT and Tlr2-/- mice after infection (P = 0.0002); (h) Mean clinical severity score of Tlr2-/- and WT after 3, 7, 14 or 21d of infection. (*** P < 0.001; ** P < 0.01; * P < 0.05)