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. 2010 Feb 3;30(5):1882–1893. doi: 10.1523/JNEUROSCI.3200-09.2010

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Copyright © 2010 the authors 0270-6474/10/301882-12$15.00/0

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Figure 4. — Effects of tolbutamide (100 μm) on NMDA receptor-mediated currents. A, Tolbutamide potentiates inward currents and blocks outward currents evoked by local application of NMDA. Currents were evoked in an STN neuron by pressure ejection of 100 μm NMDA (arrows) from a micropipette placed near the recording patch pipette. Note that outward currents follow NMDA-induced inward currents during control recordings. B, Tolbutamide has no effect on an NMDA receptor-mediated EPSC evoked in an STN neuron by focal electrical stimulation of the brain slice. This EPSC, recorded in CNQX (10 μm) and bicuculline (30 μm), was completely blocked by 50 μm AP-5 (data not shown). C, A train of 10 stimuli delivered at 200 Hz evokes AP-5-sensitive inward current but tolbutamide has no effect. D, Three trains of HFS consisting of stimuli delivered at 100 Hz for 1 s every 20 s evoke a tolbutamide-sensitive outward current. Downward deflections are artifacts caused by HFS. E, Five trains of HFS evoke an outward current that is blocked by AP-5 (50 μm). Each recording was from a different STN neuron.