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. 2010 Feb 3;30(5):1882–1893. doi: 10.1523/JNEUROSCI.3200-09.2010

Figure 5.

Figure 5.

The NMDA-evoked K-ATP conductance increase requires NO. A, Current traces show that the NOS inhibitor l-NAME (200 μm) increased the amplitude of inward current evoked by NMDA (20 μm) at −70 mV. B, Summarized I–V plots of net NMDA currents show that l-NAME (200 μm) significantly increased the amplitude of inward currents evoked by NMDA at −70 mV and reduced the slope conductance (n = 14). C, Current traces show that the NOS inhibitor 7-NINA (100 μm) increased the amplitude of inward currents evoked by NMDA (20 μm) at −70 mV. D, Summarized I–V plots of NMDA currents show that 7-NINA (100 μm) significantly increased the amplitude of inward currents evoked by NMDA at −70 mV and reduced slope conductance (n = 9). E, Current traces show that the NO scavenger carboxy-PTIO (100 μm) increased the amplitude of inward currents evoked by NMDA (20 μm) at −70 mV. F, Summarized I–V plots of NMDA current show that carboxy-PTIO (100 μm) significantly increased the amplitude of inward currents evoked by NMDA at −70 mV and reduced the slope conductance (n = 5). *p < 0.05 (two-way repeated measures ANOVA with Holm–Sidak pairwise comparison test).