Figure 6.

l-arginine evokes K-ATP currents in STN neurons. A, Current traces show that application of the NOS substrate l-arginine (10 mm) evokes a tolbutamide (100 μm)-sensitive outward current at −70 mV. B, I–V plots show that net (subtracted) currents evoked by l-arginine are antagonized by tolbutamide (n = 7). C, Current–voltage plots show that net (subtracted) currents evoked by l-arginine are antagonized by the NOS inhibitor l-NAME (200 μm; n = 4). *p < 0.05 (two-way repeated measures ANOVA with Holm–Sidak pairwise comparison test).