Figure 13.

In vivo tumor targeting with SWNTs. (a) Scheme of PEGylated SWNTs with RGD conjugation and radiolabeling. (b) Micro-PET images of mice. Arrows point to the tumors. High tumor uptake (~13 %ID/g) of SWNT–PEG₅₄₀₀–RGD is observed in the U87MG tumor (2^nd column), in contrast to the low tumor uptake (1^st column) of SWNT–PEG₂₀₀₀–RGD. The 3^rd column is a control experiment showing blocking of SWNT–PEG₅₄₀₀–RGD tumor uptake by co-injection of free c(RGDyK). The 4^th column is a control experiment showing low uptake of SWNT–PEG₅₄₀₀–RGD in integrin α_vβ₃-negative HT-29 tumor. Copyright 2007 Nature Publishing Group [44]