Table 1.

Reaction details for synthesis of 6–10

Compound	DHA (2)			Linker			Ether	BF3·OEt2	MSa	Crudeb	Product
	mg	mmol	eq.	mg	mmol	eq.	mL	μL	g	mg	mg	%
6	360	1.27	2.11	84.0	0.60	1	120	400	1.7	330	28.0	6.9
7	510	1.79	18.82	10.4	0.10	1	75	700	-	410	44.0	71.9
8	402	1.41	2.22	56.2	0.64	1	75	220	-	335	88.0	22.2
9	480	1.69	3.10	48.0	0.54	1	50	410	-	416	135.0	39.9
10	540	1.90	2.08	97.0	0.91	1	60	450	-	575	55.0	9.4

^aMS: molecular sieve.

^bCrude: crude reaction mixture after workup.