Table 2.

Antimalarial and cytotoxic activity of 1–18

	Plasmodium falciparum				Cytotoxicity
Compound	D6 clone		W2 clone		Vero
	IC50 (nM)	S.I.	IC50 (nM)	S.I.	TC50 (nM)
1	32.9	> 51	42.5	> 40	> 1,686
2	14.8	95	14.1	100	1,407
3	15.8	> 113	25.5	> 70	> 1,787
4	5.3	49	5.8	44	257
5	11.2	34	3.8	100	384
6	3.0	> 2,380	4.2	> 1,700	> 7,075
7	5.8	> 1,287	5.9	> 1,253	> 7,417
8	6.3	113	6.1	116	709
9	24.2	32	25.8	30	773
10	43.8	> 170	45.4	> 164	> 7,452
11	6.7	> 1,082	5.2	> 1,400	> 7,270
12	11.7	71	14.0	59	825
13	45.5	> 164	47.1	> 159	> 7,475
14	11.8	542	11.8	542	6,403
15	7.9	> 1,700	7.0	> 1,904	> 13,355
16	20.9	> 560	20.7	> 567	> 11,711
17	6.2	> 2,164	7.6	> 1,763	> 13,430
18	298.3	18	243.1	22	5,259
chloroquinea	41.6	> 357.9	378.3	> 39.3	> 14,881

IC₅₀: concentration causing 50% growth inhibition. TC₅₀: concentration toxic to 50% of the cells. S.I.: selectivity index [TC₅₀ (Vero)/IC₅₀ (P. falciparum)].

^aControl.