Table 4.
Anticancer and cytotoxic activity of 4–18
| Cancer cell lines |
Noncancerous cell lines |
|||||
|---|---|---|---|---|---|---|
| Compound | SK-MEL | KB | BT-549 | SK-OV-3 | Vero | LLC-PK11 |
| IC50(μM) | TC50(μM) | |||||
| 4 | 0.56 | 0.24 | 0.24 | NA | > 8.03 | 0.10 |
| 5 | 8.00 | 0.26 | 0.48 | NA | 5.60 | 0.15 |
| 6 | NA | NA | NA | NA | NA | NA |
| 7 | NA | NA | NA | NA | NA | NA |
| 8 | NA | 0.32 | 1.53 | NA | 0.18 | NC |
| 9 | 12.93 | 0.27 | 2.58 | NA | 0.43 | > 16.11 |
| 10 | 0.24 | 0.16 | 0.08 | NA | > 1.57 | 0.10 |
| 11 | NA | NA | NA | NA | NA | NA |
| 12 | NA | NA | NA | NA | NA | NA |
| 13 | 0.22 | 0.47 | 0.30 | NA | > 1.57 | 0.68 |
| 14 | NA | 0.28 | NA | NA | 2.13 | NC |
| 15 | NA | NA | NA | NA | NA | 20.76 |
| 16 | NA | NA | NA | NA | NA | 2.46 |
| 17 | NA | NA | NA | NA | NA | NA |
| 18 | 0.24 | 0.11 | 0.06 | NA | > 1.10 | 0.07 |
| doxorubicina | 1.73 | 2.04 | 1.96 | 2.04 | NC | 1.29 |
| paclitaxela | 4.10 | 0.02 | 0.02 | 0.53 | 0.53 | 4.39 |
IC50: concentration causing 50% growth inhibition. TC50: concentration toxic to 50% of the cells. SK-MEL: human malignant melanoma. KB: human epidermal carcinoma. BT-549: human breast carcinoma (ductal). SK-OV-3: human ovary carcinoma. Vero: African monkey kidney fibroblast. LLC-PK11: pig kidney epithelial. NA: not active. NC: not cytotoxic.
a
Control.