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. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Bioorg Med Chem. 2009 Oct 30;17(23):7949–7957. doi: 10.1016/j.bmc.2009.10.019

Table 5.

¹H NMR data for 5 and 6–18 (δ_H in ppm, J values in Hz)

Position	5^a	6^a	7^a	8^a	9^a	10^a	11^a	12^a	13^a	14^b	15^a	16^b	17^a	18^a
5/5′	5.35 (s)	5.45 (s) 5.40 (s)	5.49 (s)	5.40 (s)	5.36 (s) 5.41 (s)	5.37 (s) 5.43 (s)	5.8 (s) 5.9 (s)	5.44 (s) 5.43 (s)	5.39 (s)	5.65 (s) 5.72 (s)	5.42 (s)	5.69 (s)	5.35 (s)	5.33 (s) 5.40 (s)
		2.64 (m)
11/11′	2.61 (m)	2.76 (m)	2.78 (m)	2.54 (br s)	2.58 (m)	2.60 (m)	2.65 (m)	2.66 (m)	2.62 (br s)	2.78 (br s)	2.70 (m)	2.81 (br m)	2.54 (br s)	2.62 (m)
12/12′	4.773 (d, 3.8) 4.766 (d, 3.8)	4.87 (d, 3.6) 5.42 (d, 3.2)	5.45 (d, 4.0) 6.48 (d, 1.2)	4.80 (d, 3.2)	4.74 (d, 2.8) 4.84 (d, 3.6)	4.78 (d, 3.2) 4.76 (d, 3.2)	4.80 (d, 3.6) 4.82 (d, 3.6)	4.85 (d, 3.2) 4.94 (d, 3.2)	4.77 (d, 3.2) 4.84 (d, 3.2)	4.92 (d, 2.8) 4.98 (d, 3.2)	4.83 (d, 3.6)	5.06 (br s)	4.80 (d, 3.6)	4.72 (d, 3.2) 4.79 (d, 2.8) 4.81 (d, 3.2)
13/13′	0.88 (d,7.4)	0.97 (d, 7.6) 0.99 (d, 7.2)	0.99 (d, 7.2)	0.90 (d, 7.6)	0.86 (d, 7.2) 0.83 (d, 7.2)	0.88 (d, 7.2)	0.89 (d, 7.2)	0.93 (d, 7.2)	0.91 (d, 7.2)	0.90 (d, 7.2)	0.94 (d, 6.0)	0.87 (d, 7.2)	0.85 (d, 7.6)	0.86 (d, 7.2) 0.90 (d, 7.6)
14/14′	0.91 (d, 6.3)	0.93 (d, 6.0)	0.95 (d, 6.0)	0.94 (d, 6.4)	0.92 (d, 6.4)	0.91 (d, 6.0)	0.93 (d, 6.8)	0.95 (d, 6.4)	0.92 (d, 6.4)	0.85 (d, 6.8)	0.99 (d, 6.4)	0.80 (d, 6.0)	0.89 (d, 6.4)	0.925 (d, 6.4) 0.932 (d, 6.0)
15/15′	1.38 (s)	1.41 (s) 1.44 (s)	1.43 (s)	1.43 (s)	1.39 (s)	1.38 (s)	1.40 (s)	1.40 (s) 1.43 (s)	1.40 (s)	1.48 (s)	1.43 (s)	1.51 (s)	1.37 (s)	1.36 (s) 1.39 (s) 1.40 (s)
16	3.47 (dd, 10.3, 4.3) 3.84 (m)	4.40 (d, 12.4) 4.74 (d, 12.4)	-	4.01 (d, 10.8) 4.26 (d, 10.8)	3.43 (m) 3.89 (m)	3.48 (m) 3.68 (m)	4.01 (dd, 10.8, 3.2) 3.91 (m)	3.80 (m)	3.96 (dd, 3.2, 2.8) 3.57 (m)	3.76 (dd, 5.6, 10.8) 4.37 (dd, 3.6, 10.8)	4.23 (d, 17.6) 4.42 (s)	4.62 (d, 12.0) 5.04 (d, 13.6)	5.59 (m) 5.75 (m)	3.71 (dd, 3.6, 6.8) 3.86 (m)
17	3.84 (m)	-	6.48 (d, 1.2)	5.59 (br s)	4.33 (m)	3.88	3.73 (m)	3.80 (m)	3.19 (m)	5.30 (m)	-	-	5.59 (m)	3.86 (m)
18	3.40 (dd, 9.8, 5.4) 3.84 (m)	6.45 (s) 6.56 (s)	-	5.59 (br s)	5.61 (m)	1.72 (m)	3.73 (m)	3.80 (m)	3.19 (m)	3.80 (dd, 4.4, 11.2) 4.37 (dd, 3.6, 10.8)	4.53 (d, 17.2) 4.42 (s)	6.90 (s)	5.75 (m)	1.73 (m) 1.86 (m)
19	-	-	6.32 (d, 7.6)	4.01 (d, 10.8) 4.26 (d, 10.8)	5.23 (m)	3.52 (m) 3.93 (m)	3.66 (dd, 11.2, 3.6) 3.56 (m)	4.14 (br d, 8.8) 3.66 (m)	3.83 (m) 3.57 (m)	-	-	-	5.59 (m) 5.75 (m)	3.44 (m) 3.86 (m)
20	-	6.57 (s)	7.03 (d, 8.0)	-	-	-	-	-	-	-	-	6.96 (s)	-	-
21	-	-	6.50 (br d)	-	-	-	-	-	-	-	-	-	-	-
22	-	6.45 (s) 6.56 (s)	-	-	-	-	-	-	-	-	-	6.90 (s)	-	-

^a

CDCl₃.

^b

pyridine-d₅.