Table 6.
Pharmacokinetic parameters of commonly used drugs for status epilepticus[34]
| Latency (in minutes) | Duration (in hours) | |
|---|---|---|
| Lorazepam (IV) | 3–10 | 12–24 |
| Diazepam (rectal) | 5–15 | <1 |
| Diazepam (IV) | 1–5 | <1 |
| Midazolam (IM) | 5–10 | <1 |
| Midazolam (buccal) | 5–10 | <1 |
| Midazolam (IV) | 10–30 | 12–2 |
| Phenytoin (IV) | 10–30 | 12–24 |
| Fosphenytoin (IV) | 10–30 | 12–24 |
| Phenobarbitone (IV) | 5–30 | 48–72 |
| V (IV) | <20 | 8–24 |
Latency = Time interval between commencement of infusion and onset of action. Duration = The time, from onset of infusion, for which the drug may maintain adequate anticonvulsant level in the blood.