Table 1.
MSAP, PVP, and arterial blood gases in PVL- and ET-1-treated animals
Control | ET-1 | 2-wk PVL | 2-wk PVL + ET-1 | |
---|---|---|---|---|
MSAP, mmHg | 114.4±3.6 | 112.1±3.2 | 97.5±2.9* | 94.5±2.8* |
PVP, mmHg | 7.5±1.1 | 8.3±0.9 | 13.7±1.2* | 12.5±1.0* |
AaPO2, mmHg | 6.5±0.9 | 6.8±1.0 | 6.0±1.4 | 16.6±1.9* |
Values are means ± SE; n = 5–8 animals per group. MSAP, mean systemic arterial pressure; PVP, portal venous pressure; AaPO2, alveolar-arterial oxygen gradient; ET-1, endothelin-1; PVL, portal vein ligation.
P < 0.05 compared with control animals.