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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2009 Dec;10(12):819–830. doi: 10.1038/nrm2803

Figure 3.

Figure 3

Figure 3

GPCR-interacting proteins can regulate the post-endocytic trafficking of GPCRs. Following agonist-induced receptor endocytosis, some GPCRs are targeted for proteolytic and/or lysosomal degradation, while other GPCRs rapidly recycle back to the plasma membrane. As shown in panel A, the interaction between the GPCR-interacting protein GASP1 and the δ-opioid receptor (δOPR) promotes the endocytic targeting of agonist-internalized δ-opioid receptors to lysosomes, where the receptors are degraded. In contrast, as shown in panel B, the interaction between the GPCR-interacting protein NHERF-1 and the β2-adrenergic receptor (β2-AR) promotes the rapid recycling of receptors following agonist-promoted internalization.