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Effect on cell motility of the various sceptrin-derived compounds. HeLa cells were allowed to migrate in the presence of hepatocyte growth factor (HGF) (10 ng mL−1). As indicated cells were treated with sceptrin or sceptrin-derivatives (40 μM) for 24 h as described above. Control cells were treated with vehicle (H2O). Cell motility was quantified as described in Methods.
