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. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: J Med Chem. 2009 Dec 24;52(24):7950–7953. doi: 10.1021/jm901543m

Table 2.

SAR of 2-amino moiety.

graphic file with name nihms173340t9.jpg
Compound ID R” G9a IC50 (µM)
Thioglo
Assay		 Alpha-
Screen
2b graphic file with name nihms173340t10.jpg 0.33 0.23
2h graphic file with name nihms173340t11.jpg 0.68 0.20
2i graphic file with name nihms173340t12.jpg 0.55 0.51
2j graphic file with name nihms173340t13.jpg 1.6 0.81
2k graphic file with name nihms173340t14.jpg 0.91 6.5
2l graphic file with name nihms173340t15.jpg 1.1 0.90
2m graphic file with name nihms173340t16.jpg < 30%
inhibition
at 1 µM		 9.1