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. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: Genes Immun. 2008 Jun;9(4):368–378. doi: 10.1038/gene.2008.29

Figure 3.

Figure 3

(a) Dnmt1 expression in the spleen of dnMEK/CD2-rtTA mice. Double-transgenic mice given doxycycline and thus expressing the dnMEK gene show decreased Dnmt1 expression as compared to double-transgenic mice without doxycycline (0.678 ± 0.132 versus 1.194 ± 0.098 (mean ± s.e.m.); P = 0.02, n = 4). (b) Reduced Dnmt1 expression in vitro in doxycycline-treated T cells from dnMEK/CD2-rtTA mice as compared to CD2-rtTA controls. Dnmt1 mRNA levels were determined by real-time RT-PCR and normalized to GAPDH (n = 3, P = 0.028).