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. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: J Invest Dermatol. 2008 Mar 6;128(8):2024–2030. doi: 10.1038/jid.2008.41

Figure 3. Case AB.

Figure 3

Bottom panel: (1) melanoma in situ; (2) clinically, dermoscopically, and microscopically normal skin; (3) invasive melanoma of 3.0 mm thickness. Black line: surgical margin; white line: field cell margin identified by amplification of 11q13. Top panel: array CGH profile of area 3. A log 2 ratio of 0 indicates normal copy number, and narrow spikes of increased copy number indicate regions of amplification that include 11q13. Middle panel: H&E and FISH for areas 1–3. FISH images represent one plane, so not all signals are visible. A green immunofluorescent stain to Melan-A was used to aid in identifying basal melanocytes. Cells with amplification of 11q13 are highlighted by arrowheads for areas 1 and 2. Bars (H&E) = 60 μm.