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. 2010 Feb 22;5(2):e9332. doi: 10.1371/journal.pone.0009332

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Oseltamivir-resistant H1N1 viruses were incubated with MDCK cells in the presence of drugs, and CPE was determined by Neutral Red assay. Synergy volumes are plotted for each double combination, and for the triple combination as a function of increasing concentration of each drug as the third drug. Black bars, A/Mississippi/3/01 H274Y (MS H274Y); hatched bars, A/Hawaii/21/07 H274Y (HI H274Y). (A) Double combinations of amantadine/oseltamivir carboxylate (AMT/OSC), amantadine/ribavirin (AMT/RBV), and ribavirin/oseltamivir carboxylate (RBV/OSC). Triple combination of amantadine, ribavirin, and oseltamivir carboxylate as a function of (B) amantadine concentration, (C) ribavirin concentration, and (D) oseltamivir carboxylate concentration. Data are presented as the mean between 18 replicates from 6 experiments with 95% confidence intervals. The concentrations of each drug used in double and triple combinations are provided in Table S1. *P<0.05 versus double combination without drug.