Table 1.
Pharmacokinetic parameters for mice and rats dosed intravenously with Phor21-βCG(ala)
| Parameter | Mouse | Mouse | Rat |
|---|---|---|---|
| Dose (mg kg−1) | 0.8 | 8 | 6 |
| AUC0–∞ (μg · h mL−1) | 2.6 ± 0.3 | 50.8 ± 6.9 | 14.6 ± 2.5 |
| Cmax (μg mL−1) | 18.8 ± 1.4 | 88.5 ± 3.5 | 43.0 ± 4.0 |
| t½½α (h) | 0.46 ± 0.12 | 0.32 ± 0.02 | 0.13 ± 0.02 |
| t½½β (h) | ND | 5.0 ± 6.6 | 2.25 ± 1.4 |
| Cl (mL kg−1 h−1) | 313 ± 41 | 157 ± 22 | 412 ± 70 |
| Vdss (mL kg−1) | 170 ± 30 | 287 ± 32 | 666 ± 33 |
Data are means ± s.d., n = 3 or 4. Cmax, maximum plasma concentration extrapolated to time 0. t½α and t½β denote half-life of the distribution phase and the terminal elimination phase, respectively.