Table 4.
Trabecular parameters analyzed by μCT in the proximal tibia of 21-week-old female C57BL/6 mice that received no artificial loading, static (2.0 N) loading or static (2.0 N) plus dynamic (11.5 N) loading in the right tibia/fibula for 2 weeks.
| NOLOAD left | NOLOAD right | STATIC left | STATIC right | DYNAMIC + STATIC left | DYNAMIC + STATIC right | |
|---|---|---|---|---|---|---|
| 0.01–0.25 mm | ||||||
| Percent bone volume (%) | 15.2 ± 0.6 | 15.1 ± 0.6 | 14.3 ± 0.7 | 13.9 ± 0.7 | 13.9 ± 0.4 | 20.1 ± 1.1⁎ |
| Trabecular number (mm− 1) | 3.19 ± 0.12 | 3.27 ± 0.12 | 3.17 ± 0.15 | 3.15 ± 0.18 | 2.99 ± 0.14 | 3.53 ± 0.13⁎ |
| Trabecular thickness (μm) | 47.6 ± 0.5 | 46.1 ± 0.5 | 45.2 ± 0.9 | 44.4 ± 0.4# | 47.0 ± 1.4 | 56.9 ± 1.8⁎ |
| 0.25–1.25 mm | ||||||
| Percent bone volume (%) | 9.2 ± 0.2 | 9.7 ± 0.3 | 8.8 ± 0.3 | 8.9 ± 0.3 | 8.6 ± 0.3 | 13.9 ± 0.7⁎ |
| Trabecular number (mm− 1) | 1.70 ± 0.06 | 1.77 ± 0.07 | 1.68 ± 0.07 | 1.73 ± 0.07 | 1.63 ± 0.07 | 2.08 ± 0.10⁎ |
| Trabecular thickness (μm) | 54.4 ± 0.5 | 54.8 ± 0.6 | 52.7 ± 0.7 | 51.4 ± 0.7 | 52.9 ± 1.5 | 66.8 ± 0.9⁎ |
Mean ± SE (n = 7).
⁎
p < 0.05 versus left in the DYNAMIC + STATIC group by paired t-test. #p < 0.05 versus left in the NOLOAD group by one-way ANOVA followed by a post hoc Dunnett T3 test.