Table XI.
Comet assay evaluation of peripheral blood in rats exposed to one administration of EMS
| Dose (mg/kg) | TL (mean ± SD) | % Tail |
OTM |
% LMW DNA |
|||
| Mean ± SD | P-valuea | Mean ± SD | P-valuea | Mean ± SD | P-valuea | ||
| Vehicle | 13.4 ± 4.80 | 8.2 ± 1.28 | — | 0.9 ± 0.21 | — | 0.7 ± 1.21 | — |
| 25 | 14.8 ± 2.88 | 8.9 ± 1.11 | 0.1791 | 0.9 ± 0.19 | 0.2631 | 2.0 ± 2.61 | 0.1970 |
| 50 | 19.7 ± 3.24 | 10.0 ± 0.91 | +0.0085* | 1.3 ± 0.26 | +0.0040* | 5.2 ± 2.56 | +0.0043* |
| 100 | 31.3 ± 2.32 | 13.9 ± 1.32 | < +0.0001* | 2.4 ± 0.22 | < +0.0001* | 8.8 ± 3.31 | +0.0011* |
| 200 | 36.9 ± 4.97 | 20.0 ± 3.63 | < +0.0001* | 4.4 ± 1.17 | +0.0003* | 14.0 ± 4.15 | +0.0010* |
| One-tailed trend test P-value | < +0.0001* | < +0.0001* | < +0.0001* | ||||
Data based on 100 cells scored per animal; six animals per dose group.
a
One-tailed pairwise comparison of dose group to the concurrent vehicle control.
*
Statistically significant increase (+) or decrease (−) at P < 0.05.