Table VI.
Comet assay evaluation of peripheral blood in rats exposed to three administrations of EMS
| Dose (mg/kg) | TL (mean ± SD) | % Tail |
OTM |
% LMW DNA |
|||
| Mean ± SD | P-valuea | Mean ± SD | P-valuea | Mean ± SD | P-valuea | ||
| Positive | 31.6 ± 3.49 | 19.0 ± 3.71 | +0.0001* | 4.0 ± 0.95 | +0.0002* | 12.2 ± 5.34 | +0.0011* |
| Vehicle | 7.2 ± 1.98 | 6.2 ± 0.85 | — | 0.5 ± 0.09 | — | 1.2 ± 2.40 | — |
| 25 | 19.8 ± 1.88 | 11.3 ± 1.66 | < +0.0001* | 1.5 ± 0.29 | +0.0001* | 2.5 ± 2.07 | 0.1969 |
| 50 | 28.1 ± 1.33 | 15.0 ± 1.62 | < +0.0001* | 2.7 ± 0.38 | < +0.0001* | 9.2 ± 2.93 | +0.0022* |
| 100 | 34.9 ± 2.93 | 20.8 ± 4.03 | +0.0001* | 4.5 ± 1.26 | +0.0003* | 11.7 ± 6.31 | +0.0022* |
| One-tailed trend test P-value | < +0.0001* | < +0.0001* | < +0.001* | ||||
Data based on 100 cells scored per animal; six animals per dose group.
a
One-tailed pairwise comparison of dose group to the concurrent vehicle control.
*
Statistically significant increase (+) or decrease (−) at P < 0.05.