Table IX.
Clinical and microscopic evidence of liver toxicity in rats exposed to three administrations of EMS
| Dose (mg/kg) | BW gain (g) (mean ± SD) | Decreased pallora (mean ± SD) | % LMW DNA (mean ± SD) |
| Positive | 9.6 ± 7.75** | 1.5 ± 0.55** | 10.0 ± 5.93** |
| Vehicle | 23.7 ± 5.59 | 0.0 ± 0.00 | 4.8 ± 3.06 |
| 25 | 15.7 ± 8.04 | 0.0 ± 0.00 | 3.2 ± 1.94 |
| 50 | −2.5 ± 14.33** | 0.8 ± 0.75** | 7.7 ± 3.56 |
| 100 | −15.5 ± 7.09** | 2.0 ± 0.00** | 12.7 ± 4.80** |
| One-tailed trend P-value | <0.0001** | <0.0001** | <0.0001** |
a
Compared to cytoplasm of normal hepatocytes; severity score based on 1 = minimal; 2 = mild.
**
Statistically significant at P < 0.05.