Skip to main content
. Author manuscript; available in PMC: 2010 Feb 20.
Published in final edited form as: Orthod Craniofac Res. 2009 Aug;12(3):243–253. doi: 10.1111/j.1601-6343.2009.01459.x

Table 2.

Cellular pathways activated by enamel matrix derivative

All cells studied
 FGF signaling
 Transforming growth factor-β signaling
 Wnt/β-catenin signaling
PDL fibroblasts
 vascular endothelial growth factor (VEGF) signaling
 SHH pathway
Pulpal fibroblasts
 EGF signaling
 SHH pathway
 VEGF signaling
 Interleukin-6 signaling
 ERK/MAPK signaling
 Estrogen receptor signaling
Bone cells
 PPAR signaling
 Nuclear factor-κB signaling
 Estrogen receptor signaling

PDL, periodontal ligament; SHH, Sonic Hedgehog; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; PPAR, peroxisome proliferator-activated receptor.