Figure 1.

Comparative expression of mRNA for P2Y₂ receptors (A), P2Y₆ receptors (B) and the ratio P2Y₆/P2Y₂ (C) in aortic arches of old (18 months) atherosclerotic apoE^–/– and plaque-free WT mice (18 months) on regular chow. The expression of the P2Y₆ receptor was significantly increased in arteries with atherosclerotic lesions. β-Actin was used as an endogenous reference gene and the mean value of the WT was used as a calibrator and set to one. Results show mean and SEM, n= 6 (apoE^–/–) or n= 4 (WT). *P < 0.05, ***P < 0.001. WT, wild-type.