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. 2009 Dec 24;159(2):326–336. doi: 10.1111/j.1476-5381.2009.00497.x

Figure 6.

Figure 6

iNOS (A) and IL-6 (B) mRNA expression in J774 macrophages after stimulation (6 h) with 1 mM UDP, with and without suramin (100 and 300 µM) or PPADS (10 and 30 µM). The UDP-induced up-regulation of iNOS and IL-6 was antagonized by both non-selective purinoceptor antagonists. Results show mean and SEM of four independent experiments. *P < 0.05, **P < 0.01 different from 1 mM UDP, anova and Dunnett's test. IL-6, interleukin 6; iNOS, inducible nitric oxide synthase; PPADS, pyridoxal-phosphate-6-azophenyl-2′-4′-disulphonic acid; UDP, uridine 5′ diphosphate.