Figure 7.
Cross-sectional plaque area at the level of the aortic root in control, suramin (50 mg·kg−1·day−1), and PPADS (25 mg·kg−1·day−1)-treated apoE–/– mice (4 months) on a Western-type diet (A). Plaque size was significantly lower in mice treated with suramin or PPADS. Relative areas of macrophages (mac-3, B) and SMCs (α-SMC actin, C), and cell proliferation (percentage PCNA-positive nuclei, D) were not influenced by suramin or PPADS. Results show mean and SEM, n= 6. *P < 0.05, **P < 0.01, Kruskal Wallis anova. PCNA, proliferating cell nuclear antigen; PPADS, pyridoxal-phosphate-6-azophenyl-2′-4′-disulphonic acid; SMC, smooth muscle cell.